NICOVID Research team
NICOVID Research team
Introducing SARS-CoV-2, New Coronavirus
Introducing SARS-CoV-2, New Coronavirus
The status of the international crisis in global health
The status of the international crisis in global health
Proposed treatments of COVID-19 disease
Proposed treatments of COVID-19 disease

Proposed treatments of COVID-19 disease

Clinical symptoms of the patients with COVID-19 are mostly included in fever, cough, fatigue, sputum production, dyspnea, sore throat, and headache. At present, there are few antivirus strategies in particular, but several strong antivirus medicines are being urgently studied. At present, there is no definite and specific treatment for this disease, and antivirus medicines applied in severe cases are mostly related to the treatment of other known viruses such as HIV and flu. Hence, their evident treatment effects were not reported well. On the one hand, in milder cases that do not need hospitalization, there is the possibility of improvement for the disease period.

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The structure and mechanism of Coronavirus

The SARS-CoV-2 virus is a single-stranded virus with RNA (++ssRNA). The important proteins in the structure of the virus are included in Capsid proteins, membrane proteins, spike proteins, and intracellular proteins.

Among these four proteins, Spike protein and membrane proteins are of high importance. Spike protein helps virus connection to host cell and membrane proteins to the virus in building capsule and structure of the virus. Angiotensin-Converting Enzyme 2 protein are among the present receptors in the level of human body cells, which SARS-CoV-2 connects to it, and then the genome enters the host cell. ACE-2 is noted in different organs such as Lung, kidney, and small intestine, which these organs are among the main purposes of the SARS-CoV-2 virus. Due to special importance which ACE-2 has in the pathogenesis of COVID-19, building antibodies against this receptor is mostly considered for the treatment of this disease.

 

The status of the international crisis in global health

On 30 January 2020, WHO officially announced pandemic COVID-19 arising SARS-CoV-2 new coronavirus as an international critical status in public health. The cause of COVID-19, which was not previously known in humans, today it is known as severe acute respiratory syndrome coronavirus 2, and it was observed in Wuhan, China, for the first time and caused continuous and extensive prevalence.

At present, this virus is epidemic in 185 countries, and every day the number of suffering and dead people is increased due to this disease. The pieces of evidence increasingly show sustainable human-to-human transmission around the world, and the amount of its death is reported at about 3.4%.

Due to published statistics by Johns Hopkins University up to now (30 April 2020), more than 3 million and 100 thousand people in the world suffered from this disease which among them, 227000 people died. Due to the high importance in which COVID-19 is considered, many types of research around the world is being done or handled.

In Iran, due to official statistics of the Ministry of Health and Medical Education up to now (2020-04-30), the whole number of people with COVID-19 reached more than 94000 people, and 6000 people or more died. The entire number of recovered people is announced more than 75000 people, and in addition, it is announced that more than 3100 patients are in severe condition and under care.

Economic effects of new Coronavirus

In addition to the high amount of suffering and death in the world, SARS-CoV-2 Virus has had disastrous damages for the economy of the world and our country. Due to economic experts, the risk of Covid-19 is the extent that is known as a beginning on the occurrence of a recession in the global economy (Tasnim News Agency).
Of course, the amount of the efficiency of Coronavirus prevalence on different economies is not the same, and the prevalence of this virus can have a considerable effect on the economies rely on income arising tourism.
Among the global impacts of Coronavirus prevalence, the increase of unemployment in the world, imposing heavy shocks to the world economy, heavy damage to the foreign business of China, and other countries involving Corona, the probability for closing world doors to foreign business, etc. can be noted.
The prevalence of Coronavirus in Iran had many effects on the internal economy and is continued. Due to economic experts in Iran, the reality is more complicated because, in addition to global economic damages, Iran's economy will have more damages due to dependency on oil, international sanctions, a negative growth of the economy, high inflation, etc.

now our suggestion in this study…

Nowadays, there are multiple medicinal plants that can be used in the cycle of treatment due to the idea of many physicians and experts in plant sciences. Almost 11 percent of important medicines in medicinal list of world health organization has uniquely plant origin. Medicinal plants are classified among food complements; hence they can be produced and sold with the supervision of food and medicine organizations.